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Article

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Accepted version

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2014-01-30

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/53332

The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression

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http://dx.doi.org/10.1016/j.ijpharm.2013.11.029

Abstract

The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses.

Subject

Comprimits (Medicina), Medicació oral, Excipients, Control de qualitat, Medicaments d'alliberament retardat, Tecnologia farmacèutica, Pólvores (Farmàcia)

Subject (English)

Tablets (Medicine), Oral medication, Excipients, Quality control, Delayed-action drugs, Pharmaceutical technology, Powders (Pharmacy)

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

SAURÍ DURAN, Jaume, et al. The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression. International Journal of Pharmaceutics. 2014. Vol. 461, num. 1-2, pags. 38-45. ISSN 0378-5173. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/53332

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