The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression

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dc.contributor.authorSaurí Duran, Jaume
dc.contributor.authorMillán, D.
dc.contributor.authorSuñé i Negre, Josep M. (Josep Maria)
dc.contributor.authorPérez Lozano, Pilar
dc.contributor.authorSarrate Arjona, Rocio
dc.contributor.authorFábregas, A. (Anna)
dc.contributor.authorCarrillo Sánchez, Carolina
dc.contributor.authorMiñarro Carmona, Montserrat
dc.contributor.authorTicó Grau, Josep R.
dc.contributor.authorGarcía Montoya, Encarna
dc.date.accessioned2014-04-08T09:05:35Z
dc.date.available2014-04-08T09:05:35Z
dc.date.issued2014-01-30
dc.date.updated2014-04-08T09:05:36Z
dc.description.abstractThe SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses.
dc.format.extent8 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec630651
dc.identifier.issn0378-5173
dc.identifier.urihttps://hdl.handle.net/2445/53332
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1016/j.ijpharm.2013.11.029
dc.relation.ispartofInternational Journal of Pharmaceutics, 2014, vol. 461, num. 1-2, p. 38-45
dc.relation.urihttp://dx.doi.org/10.1016/j.ijpharm.2013.11.029
dc.rights(c) Elsevier B.V., 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
dc.subject.classificationComprimits (Medicina)
dc.subject.classificationMedicació oral
dc.subject.classificationExcipients
dc.subject.classificationControl de qualitat
dc.subject.classificationMedicaments d'alliberament retardat
dc.subject.classificationTecnologia farmacèutica
dc.subject.classificationPólvores (Farmàcia)
dc.subject.otherTablets (Medicine)
dc.subject.otherOral medication
dc.subject.otherExcipients
dc.subject.otherQuality control
dc.subject.otherDelayed-action drugs
dc.subject.otherPharmaceutical technology
dc.subject.otherPowders (Pharmacy)
dc.titleThe use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))