Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

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dc.contributor.authorPinyol, Roser
dc.contributor.authorSia, Daniela
dc.contributor.authorLlovet i Bayer, Josep Maria
dc.date.accessioned2020-01-08T08:42:38Z
dc.date.available2020-01-08T08:42:38Z
dc.date.issued2019-01-07
dc.date.updated2020-01-08T08:34:35Z
dc.description.abstractNext-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC.See related article by Harding et al.©2019 American Association for Cancer Research.ca
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec700752
dc.identifier.idimarina4217699
dc.identifier.issn1078-0432
dc.identifier.pmid30617138
dc.identifier.urihttps://hdl.handle.net/2445/147198
dc.language.isoengca
dc.publisherAmerican Association for Cancer Researchca
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1158/1078-0432.ccr-18-3778
dc.relation.ispartofClinical Cancer Research, 2019, vol. 25, num. 7, p. 2021-2023
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/667273/EU//HEP-CAR
dc.relation.urihttps://doi.org/10.1158/1078-0432.ccr-18-3778
dc.rights(c) American Association for Cancer Research, 2019
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.sourceArticles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
dc.subject.classificationMarcadors bioquímics
dc.subject.classificationCàncer de fetge
dc.subject.otherBiochemical markers
dc.subject.otherLiver cancer
dc.titleImmune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCCca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/acceptedVersion

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