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Article

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Accepted version

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2019-01-07

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/147198

Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

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https://doi.org/10.1158/1078-0432.ccr-18-3778

Abstract

Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC.See related article by Harding et al.©2019 American Association for Cancer Research.

Subject

Marcadors bioquímics, Càncer de fetge

Subject (English)

Biochemical markers, Liver cancer

Citation

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

Citation

PINYOL, Roser, SIA, Daniela and LLOVET I BAYER, Josep Maria. Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC. Clinical Cancer Research. 2019. Vol. 25, num. 7, pags. 2021-2023. ISSN 1078-0432. [consulted: 16 of June of 2026]. Available at: https://hdl.handle.net/2445/147198

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