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Article

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Published version

Publication date

2018-03-01

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cc by (c) Urrea Zazurca et al., 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/172791

Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons

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https://doi.org/10.1007/s12035-017-0451-4

Abstract

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils.

Subject

Alfa-sinucleïna, Prions

Subject (English)

Alpha-synuclein, Prions

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Publicacions de projectes de recerca finançats per la UE

Citation

URREA ZAZURCA, Laura, et al. Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons. Molecular Neurobiology. 2018. Vol. 55, num. 3, pags. 1847-1860. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/172791

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