Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons

Vista senzilla d'ítem
dc.contributor.authorUrrea Zazurca, Laura
dc.contributor.authorSegura Feliu, Miriam
dc.contributor.authorMasuda-Suzukake, Masami
dc.contributor.authorHervera Abad, Arnau
dc.contributor.authorPedraz López, Lucas
dc.contributor.authorGarcía Aznar, José Manuel
dc.contributor.authorVila, Miquel
dc.contributor.authorSamitier i Martí, Josep
dc.contributor.authorTorrents Serra, Eduard
dc.contributor.authorFerrer, Isidro (Ferrer Abizanda)
dc.contributor.authorGavín Marín, Rosalina
dc.contributor.authorHagesawa, Masato
dc.contributor.authorRío Fernández, José Antonio del
dc.date.accessioned2020-12-15T18:21:14Z
dc.date.available2020-12-15T18:21:14Z
dc.date.issued2018-03-01
dc.date.updated2020-12-04T12:33:49Z
dc.description.abstractThe cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid28229331
dc.identifier.urihttps://hdl.handle.net/2445/172791
dc.language.isoeng
dc.publisherSpringer
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1007/s12035-017-0451-4
dc.relation.ispartofMolecular Neurobiology, 2018, vol. 55, num. 3, p. 1847-1860
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/228685/EU//BOND
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/278486/EU//DEVELAGE
dc.relation.urihttps://doi.org/10.1007/s12035-017-0451-4
dc.rightscc by (c) Urrea Zazurca et al., 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.sourceArticles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
dc.subject.classificationAlfa-sinucleïna
dc.subject.classificationPrions
dc.subject.otherAlpha-synuclein
dc.subject.otherPrions
dc.titleInvolvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

Fitxers

Paquet original

Mostrant 1 - 2 de 2
Miniatura
Nom:
UrreaL.pdf
Mida:
17.89 MB
Format:
Adobe Portable Document Format
Descripció:
Original Article
Descarregar
Miniatura
Nom:
UrreaL_Err.pdf
Mida:
271.06 KB
Format:
Adobe Portable Document Format
Descripció:
Erratum
Descarregar

Col·leccions

Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Publicacions de projectes de recerca finançats per la UE