Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons

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dc.contributor.authorUrrea Zazurca, Laura
dc.contributor.authorSegura Feliu, Miriam
dc.contributor.authorMasuda-Suzukake, Masami
dc.contributor.authorHervera Abad, Arnau
dc.contributor.authorPedraz López, Lucas
dc.contributor.authorGarcía Aznar, José Manuel
dc.contributor.authorVila, Miquel
dc.contributor.authorSamitier i Martí, Josep
dc.contributor.authorTorrents Serra, Eduard
dc.contributor.authorFerrer, Isidro (Ferrer Abizanda)
dc.contributor.authorGavín Marín, Rosalina
dc.contributor.authorHagesawa, Masato
dc.contributor.authorRío Fernández, José Antonio del
dc.date.accessioned2020-12-15T18:21:14Z
dc.date.available2020-12-15T18:21:14Z
dc.date.issued2018-03-01
dc.date.updated2020-12-04T12:33:49Z
dc.description.abstractThe cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid28229331
dc.identifier.urihttps://hdl.handle.net/2445/172791
dc.language.isoeng
dc.publisherSpringer
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1007/s12035-017-0451-4
dc.relation.ispartofMolecular Neurobiology, 2018, vol. 55, num. 3, p. 1847-1860
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/228685/EU//BOND
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/278486/EU//DEVELAGE
dc.relation.urihttps://doi.org/10.1007/s12035-017-0451-4
dc.rightscc by (c) Urrea Zazurca et al., 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.sourceArticles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
dc.subject.classificationAlfa-sinucleïna
dc.subject.classificationPrions
dc.subject.otherAlpha-synuclein
dc.subject.otherPrions
dc.titleInvolvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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