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Article

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Accepted version

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2018

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/162875

Polymorphism of Sildenafil: A New Metastable Desolvate

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https://doi.org/10.1021/acs.cgd.8b00683

Abstract

A new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of active pharmaceutical ingredients.

Subject

Estructura cristal·lina (Sòlids), Molècules, Dissolvents

Subject (English)

Layer structure (Solids), Molecules, Solvents

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Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

Citation

BARBAS CAÑERO, Rafael, FONT BARDIA, Ma. Mercedes and PROHENS LÓPEZ, Rafael. Polymorphism of Sildenafil: A New Metastable Desolvate. Crystal Growth & Design. 2018. Vol. 18, num. 7, pags. 3740-3746. ISSN 1528-7483. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/162875

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