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Polymorphism of Sildenafil: A New Metastable Desolvate

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dc.contributor.authorBarbas Cañero, Rafael
dc.contributor.authorFont Bardia, Ma. Mercedes
dc.contributor.authorProhens López, Rafael
dc.date.accessioned2020-05-28T16:43:10Z
dc.date.available2020-05-28T16:43:10Z
dc.date.issued2018
dc.date.updated2020-05-28T16:43:10Z
dc.description.abstractA new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of active pharmaceutical ingredients.
dc.format.extent27 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec693055
dc.identifier.issn1528-7483
dc.identifier.urihttps://hdl.handle.net/2445/162875
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/acs.cgd.8b00683
dc.relation.ispartofCrystal Growth & Design, 2018, vol. 18, num. 7, p. 3740-3746
dc.relation.urihttps://doi.org/10.1021/acs.cgd.8b00683
dc.rights(c) American Chemical Society , 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)
dc.subject.classificationEstructura cristal·lina (Sòlids)
dc.subject.classificationMolècules
dc.subject.classificationDissolvents
dc.subject.otherLayer structure (Solids)
dc.subject.otherMolecules
dc.subject.otherSolvents
dc.titlePolymorphism of Sildenafil: A New Metastable Desolvate
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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