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Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD.
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The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
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SALA VILA, Aleix, HARRIS, William s., COFÁN PUJOL, Montserrat, PÉREZ-HERAS, Ana maria, PINTÓ SALA, Xavier, LAMUELA RAVENTÓS, Rosa ma., COVAS PLANELLS, María isabel, ESTRUCH RIBA, Ramon, ROS RAHOLA, Emilio. Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD.. _British Journal of Nutrition_. 2011. Vol. 106, núm. 3, pàgs. 425-431. [consulta: 30 de gener de 2026]. ISSN: 0007-1145. [Disponible a: https://hdl.handle.net/2445/46583]