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2018-08

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cc by-nc-nd (c) Hinzen, Wolfram et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/127567

A systematic linguistic profile of spontaneous narrative speech in pre-symptomatic and early stage Huntington's disease.

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Recurs relacionat

https://doi.org/10.1016/j.cortex.2017.07.022

Resum

Cognitive decline accompanying the clinically more salient motor symptoms of Hunting- ton's disease (HD) has been widely noted and can precede motor symptoms onset. Less clear is how such decline bears on language functions in everyday life, though a small number of experimental studies have revealed difficulties with the application of rule- based aspects of language in early stages of the disease. Here we aimed to determine whether there is a systematic linguistic profile that characterizes spontaneous narrative speech in both pre-manifest and/or early manifest HD, and how it is related to striatal degeneration and neuropsychological profiles. Twenty-eight early-stage patients (19 manifest and 9 gene-carriers in the pre-manifest stage), matched with 28 controls, participated in a story-telling task. Speech was blindly scored by independent raters ac- cording to fine-grained linguistic variables distributed over 5 domains for which composite scores were computed (Quantitative, Fluency, Reference, Connectivity, and Concordance). Voxel-based morphometry (VBM) was used to link specific brain degeneration patterns to loci of linguistic decline. In all of these domains, significant differences were observed between groups. Deficits in Reference and Connectivity were seen in the pre-manifest stage, where no other neuropsychological impairment was detected. Among HD patients, there was a significant positive correlation only between the values in the Quantitative domain and gray matter volume bilaterally in the putamen and pallidum. These results fill the gap of qualitative data of spontaneous narrative speech in HD and reveal that HD is characterized by systematic linguistic impairments leading to dysfluencies and disorga- nization in core domains of grammatical organization. This includes the referential use of noun phrases and the embedding of clauses, which mediate crucial dimensions of meaning in language in its normal social use. Moreover, such impairment is seen prior to motor symptoms onset and when standardized neuropsychological test profiles are otherwise normal

Matèries

Corea de Huntington, Gramàtica, Ganglis basals

Matèries (anglès)

Huntington's chorea, Grammar, Basal ganglia

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Col·leccions

Articles publicats en revistes (Filologia Catalana i Lingüística General)
<b>Publicacions de projectes de recerca finançats per la UE</b>
Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

HINZEN, Wolfram, ROSSELLÓ XIMENES, Joana, MOREY, Caty, CAMARA MANCHA, Estela, GARCÍA-GORRO, Clara, SALVADOR, Raymond, DIEGO BALAGUER, Ruth de. A systematic linguistic profile of spontaneous narrative speech in pre-symptomatic and early stage Huntington's disease.. _Cortex_. 2018. Vol. 100, núm. 71-83. [consulta: 21 de gener de 2026]. ISSN: 0010-9452. [Disponible a: https://hdl.handle.net/2445/127567]

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