Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

650077.pdf (1.36 MB)

Document type

Article

Version

Accepted version

Publication date

2014-04-15

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/169713

New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1016/j.jorganchem.2014.01.027

Abstract

A new family of 'FeII(h5-C5H5)' half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UVeVis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P21/c and monoclinic P21/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin.

Subject

Compostos organometàl·lics, Cèl·lules canceroses, Apoptosi

Subject (English)

Organometallic compounds, Cancer cells, Apoptosis

Citation

Collections

Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

Citation

VALENTE, A., et al. New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells. Journal of Organometallic Chemistry. 2014. Vol. 756, num. 52-60. ISSN 0022-328X. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/169713

Export metadata

JSON - METS

Share record