New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells

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dc.contributor.authorValente, A.
dc.contributor.authorSantos, A.M.
dc.contributor.authorCôrte-Real, L.
dc.contributor.authorRobalo, M.P.
dc.contributor.authorMoreno Martínez, Virtudes
dc.contributor.authorFont Bardia, Ma. Mercedes
dc.contributor.authorCalvet Pallàs, Maria Teresa
dc.contributor.authorLorenzo, Julia
dc.contributor.authorGarcia, M.E.
dc.date.accessioned2020-07-30T17:10:56Z
dc.date.available2020-07-30T17:10:56Z
dc.date.issued2014-04-15
dc.date.updated2020-07-30T17:10:56Z
dc.description.abstractA new family of 'FeII(h5-C5H5)' half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UVeVis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P21/c and monoclinic P21/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin.
dc.format.extent35 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec650077
dc.identifier.issn0022-328X
dc.identifier.urihttps://hdl.handle.net/2445/169713
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.jorganchem.2014.01.027
dc.relation.ispartofJournal of Organometallic Chemistry, 2014, vol. 756, p. 52-60
dc.relation.urihttps://doi.org/10.1016/j.jorganchem.2014.01.027
dc.rights(c) Elsevier B.V., 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)
dc.subject.classificationCompostos organometàl·lics
dc.subject.classificationCèl·lules canceroses
dc.subject.classificationApoptosi
dc.subject.otherOrganometallic compounds
dc.subject.otherCancer cells
dc.subject.otherApoptosis
dc.titleNew iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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