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2022-10-01

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cc-by-nc (c) Rubín-García, M. et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/206726

Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A CrossSectional Analysis in a Population at High Cardiovascular Risk

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https://doi.org/10.1161/JAHA.122.026053

Resum

Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. This cross- sectional analysis involved baseline data of 6332 participants. Food polyphenol con- tent was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, −0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, −0.27 to −0.06]) and hydroxycinnamic acids (β coefficient, −0.19 [95% CI, −0.3 to −0.09]), alkylmethoxyphenols (β coefficient, −0.2 [95% CI, −0.31 to −0.1]), and methoxyphenols (β coefficient, −0.24 [95% CI, −0.34 to −0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71– 0.95]; PR, 0.82 [95% CI, 0.71– 0.95]; PR, 0.80 [95% CI, 0.70– 0.92]; and PR, 0.79 [95% CI, 0.69– 0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly as- sociated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02– 0.26]) but not with hyperuricemia.

Matèries

Malalties cardiovasculars, Hiperuricèmia

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Cardiovascular diseases, Hyperuricemia

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Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Medicina)

Citació

RUBÍN GARCÍA, María, VITELLI STORELLI, Facundo, ÁLVAREZ ÁLVAREZ, Laura, MARTÍNEZ-GONZÁLEZ, Miguel ángel, SALAS SALVADÓ, Jordi, CORELLA PIQUER, Dolores, HERNÁEZ CAMBA, Álvaro, MARTÍNEZ, J. alfredo, ALONSO GÓMEZ, Ángel m., WÄRNBERG, Julia, VIOQUE, Jesús, ROMAGUERA, Dora, LÓPEZ MIRANDA, José, ESTRUCH RIBA, Ramon, TINAHONES, Francisco j., SERRA MAJEM, Lluís, CANO IBÁÑEZ, Naomi, TUR, Josep antoni, MARCOS DELGADO, Alba, TRESSERRA I RIMBAU, Anna, PINTÓ SALA, Xavier, DELGADO RODRÍGUEZ, Miguel, MATÍA MARTÍN, Pilar, VIDAL, Josep, VÁZQUEZ, Clotilde, DAIMIEL, Lidia, ROS RAHOLA, Emilio, VÁZQUEZ RUIZ, Zenaida, BABIO, Nancy, BARRAGÁN, Rocío, CASTAÑER NIÑO, Olga, RAZQUIN, Cristina, TOJAL SIERRA, Lucas, GÓMEZ GRACIA, Enrique, GONZÁLEZ PALACIOS, Sandra, MOREY, Marga, GARCÍA RIOS, Antonio, CASTRO-BARQUERO, Sara, BERNAL LÓPEZ, M. rosa, SANTOS LOZANO, José manuel, RUIZ CANELA, Miguel, CASTRO SALOMÓ, Antoni, PASCUAL CASTELLÓ, Eva cristina, MOLDON, Verónica, BULLÓN VELA, Vanessa, SORTO SANCHEZ, Carolina, CENOZ OSINAGA, Juan carlos, GUTIÉRREZ, Liliana, MENGUAL, Maira, LAMUELA RAVENTÓS, Rosa ma., MARTÍN SÁNCHEZ, Vicente. Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A CrossSectional Analysis in a Population at High Cardiovascular Risk. _Journal of the American Heart Association_. 2022. Vol. 11, núm. 20. [consulta: 20 de gener de 2026]. ISSN: 2047-9980. [Disponible a: https://hdl.handle.net/2445/206726]

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