Synergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems

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dc.contributor.authorRudilla Mateo, Héctor
dc.contributor.authorFusté i Domínguez, Ester
dc.contributor.authorCajal Visa, Yolanda
dc.contributor.authorRabanal Anglada, Francesc
dc.contributor.authorVinuesa Aumedes, Teresa
dc.contributor.authorViñas, Miquel
dc.date.accessioned2016-11-02T09:16:37Z
dc.date.available2016-11-02T09:16:37Z
dc.date.issued2016-09-12
dc.date.updated2016-11-02T09:16:42Z
dc.description.abstractThe aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem.
dc.format.extent12 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec663969
dc.identifier.issn1420-3049
dc.identifier.pmid27626405
dc.identifier.urihttps://hdl.handle.net/2445/103103
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/molecules21091223
dc.relation.ispartofMolecules, 2016, vol. 21, num. 9, p. 1223
dc.relation.urihttps://doi.org/10.3390/molecules21091223
dc.rightscc-by (c) Rudilla, Héctor et al., 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)
dc.subject.classificationPseudomonas
dc.subject.classificationSíntesi de pèptids
dc.subject.classificationPèptids
dc.subject.classificationBiofilms
dc.subject.classificationAntibiòtics
dc.subject.otherPseudomonas
dc.subject.otherPeptide synthesis
dc.subject.otherPeptides
dc.subject.otherBiofilms
dc.subject.otherAntibiotics
dc.titleSynergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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